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AR Gene Polymorphisms

Meaning

AR Gene Polymorphisms represent common variations in the DNA sequence of the Androgen Receptor (AR) gene, predominantly involving the length of the CAG trinucleotide repeat segment within the gene’s coding region. These genetic variations directly influence the structural integrity and functional efficiency of the resulting androgen receptor protein. Clinically, these polymorphisms are crucial determinants of an individual’s tissue sensitivity and response to circulating androgens, such as testosterone and dihydrotestosterone. The subtle differences in receptor function can significantly modulate the expression of androgen-dependent traits.