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Aquaporin Four Channels

Meaning

Aquaporin Four Channels are integral membrane proteins, specifically the Aquaporin-4 isoform, that form selective pores for water transport across the cell membranes of astrocytes in the central nervous system. These channels are strategically concentrated at the perivascular endfeet of astrocytes, forming a critical component of the brain’s fluid management infrastructure. The proper functioning and polarized distribution of these channels are essential for regulating brain water homeostasis and facilitating interstitial fluid exchange. Their activity directly impacts the overall health and functional integrity of neural tissues.