Question 1

What is the Meaning of Aquaglyceroporins?

Accepted Answer

Aquaglyceroporins are a specific subclass of membrane channel proteins belonging to the aquaporin family. They are responsible for the facilitated transport of water, glycerol, and other small, uncharged solutes like urea across biological membranes. These channels are pivotal in regulating cellular volume, skin hydration, and lipid metabolism within various tissues.

Question 2

What is the Origin of Aquaglyceroporins?

Accepted Answer

The name is a compound term derived from Latin and Greek roots: aqua (water), glycerol (a three-carbon alcohol), and poros (pore or channel), combined with the suffix -in for protein. The term arose from the discovery and characterization of these specialized membrane transporters, distinguishing them from simple aquaporins which primarily transport only water. This nomenclature clearly reflects their dual transport capability.

Question 3

What is the Mechanism of Aquaglyceroporins?

Accepted Answer

Functionally, aquaglyceroporins form a narrow pore structure embedded within the cell membrane, allowing solutes to pass down their concentration gradient. A critical constriction point and specific amino acid residues within the channel selectively filter for glycerol and water molecules, excluding ions like protons to maintain cellular electrochemical balance. This transport activity is essential for glycerol efflux from adipocytes during lipolysis and for maintaining skin barrier function and hydration.

Aquaglyceroporins

Meaning

Origin

Mechanism

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