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AQP4 Water Channels

Meaning

AQP4 Water Channels are integral membrane proteins, specifically Aquaporin-4, that function as highly selective pores facilitating the rapid, passive movement of water across cell membranes. These channels are abundantly expressed on the end-feet of astrocytes, glial cells that envelop brain capillaries and are a critical component of the blood-brain barrier interface. Their primary role in the central nervous system relates to maintaining osmotic balance and facilitating the clearance of metabolic waste products. Optimal function of these channels is essential for neuroendocrine health.