What is the Origin of Aptamer Biosensor?

The term "aptamer" is derived from the Latin word aptus, meaning "to fit," and the Greek word meros, meaning "part," referencing the molecule's specific, lock-and-key binding affinity. Aptamers themselves are developed through a laboratory process called Systematic Evolution of Ligands by Exponential enrichment, or SELEX, which selects for the highest-affinity binding molecules. This technology has been adapted from its initial molecular biology roots into a cutting-edge tool for clinical diagnostics and point-of-care testing.

What is the Mechanism of Aptamer Biosensor?

The biosensor operates on a principle of target-induced conformational change within the aptamer structure upon binding to the hormone molecule. This binding event triggers a measurable physical change, which is then transduced into a quantifiable electrical, fluorescent, or colorimetric signal by the sensor's electronic or optical components. For hormonal applications, the sensor’s electrochemical signal is directly proportional to the concentration of the circulating or localized hormone, enabling the non-invasive tracking of hormonal fluctuations in biofluids like sweat or saliva.

Aptamer Biosensor ∞ Area

Aptamer Biosensor

Meaning

An Aptamer Biosensor is an analytical device that utilizes a short, single-stranded nucleic acid or peptide molecule, known as an aptamer, as its molecular recognition element. This sophisticated technology is designed to detect and quantify target molecules, such as specific hormones or their metabolites, with high sensitivity and precision in a biological sample. These sensors offer a non-invasive, rapid alternative to traditional laboratory assays, facilitating personalized, real-time monitoring of key endocrine biomarkers.