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Appetite Hormone Resistance

Meaning

Appetite Hormone Resistance is a physiological state where target tissues, particularly within the hypothalamus, become desensitized to the regulatory signals of key appetite-modulating hormones like leptin and insulin. This resistance disrupts the body’s accurate perception of satiety and energy status, often leading to persistent hunger and dysregulated energy intake. Clinically, this phenomenon is a significant driver of weight gain and metabolic dysfunction. It represents a critical failure in the homeostatic control of energy balance.