A clinical objective focused on restoring the balanced, appropriate functioning of the body’s primary hormones that govern hunger, satiety, and energy balance. The goal is to correct aberrant signaling patterns that contribute to metabolic imbalance and weight management challenges.
Origin
This phrase integrates ‘Appetite Hormone’ (e.g., ghrelin, leptin, PYY), ‘Dysregulation’ (impaired control), and ‘Reversal’ (the act of returning to a functional state). It reflects a therapeutic approach in metabolic endocrinology.
Mechanism
Reversal is achieved through targeted interventions, often encompassing lifestyle modifications, chrononutrition, or pharmacological agents, that improve peripheral tissue sensitivity to key signals like leptin and insulin. This re-sensitization and synchronization normalize the communication between the gastrointestinal tract, adipose tissue, and the hypothalamic centers controlling energy intake, thereby correcting the homeostatic set point.
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