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APP/PS1 Mice

Meaning

APP/PS1 Mice refers to a double transgenic mouse model genetically engineered to express mutated human genes associated with familial Alzheimer’s disease, specifically the Amyloid Precursor Protein (APP) and Presenilin 1 (PS1). This specialized animal model is widely utilized in neuroscience and endocrinology research to rapidly recapitulate key pathological features of Alzheimer’s, including the formation of amyloid-beta plaques in the brain. Scientists employ these mice to investigate disease progression, test novel therapeutic interventions, and study the intricate interplay between hormonal status and neurodegeneration. The model provides a living system to explore how endocrine factors, such as estrogen and stress hormones, modulate brain pathology.