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APOE

Meaning

Apolipoprotein E is a protein involved in lipid metabolism and cholesterol transport throughout the body, including the brain. It is a critical component of very-low-density lipoproteins and chylomicrons, facilitating their clearance by receptors. The gene encoding this protein exhibits polymorphisms, specifically the ε2, ε3, and ε4 alleles, which significantly influence an individual’s lipid profile and risk for cardiovascular and neurodegenerative conditions. Understanding one’s APOE genotype provides valuable insights into personalized health and longevity strategies.