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Apathy Neurochemical Correlates

Meaning

This refers to the specific neurotransmitter and neuromodulator imbalances or dysfunctions in the central nervous system that are objectively associated with the subjective experience of apathy, defined as a lack of motivation, interest, or emotional indifference. Clinical assessment often seeks to identify measurable changes in brain chemistry that underpin a patient’s diminished capacity for goal-directed behavior. Apathy is not merely sadness but a distinct state of reduced self-initiated activity that requires biological attention.