AOD-9604 is a synthetic peptide fragment derived from the C-terminus of the human growth hormone (HGH) molecule, specifically amino acids 177-191. This compound is primarily defined by its selective metabolic action, which targets adipose tissue to promote fat breakdown. It is clinically distinct from full-length HGH because it avoids stimulating the Insulin-like Growth Factor-1 (IGF-1) axis or impacting glucose homeostasis significantly. The peptide represents a targeted pharmacological approach to body composition modulation.
Origin
The development of AOD-9604 originated from extensive research into the structure-function relationship of the natural Growth Hormone protein. Scientists successfully isolated the specific region of the HGH molecule that was solely responsible for its potent lipolytic, or fat-mobilizing, effects. This pharmaceutical origin allowed for the creation of a compound that maintains the metabolic benefits of HGH without the systemic side effects associated with the complete hormone structure. This selective design is a hallmark of modern peptide therapeutics.
Mechanism
The primary mechanism involves direct engagement with receptors on adipocytes, the fat cells, to stimulate lipolysis and inhibit the formation of new fat, a process called lipogenesis. It achieves this by mimicking the specific fat-burning domain of the HGH molecule. This targeted interaction promotes the efficient release of stored triglycerides from fat cells into the bloodstream for subsequent oxidation and energy utilization. The selective action ensures a metabolic shift toward fat loss without inducing widespread cellular proliferation.
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