What is the Origin of AOD-9604 Lipolysis?

The term originates from the pharmaceutical development and peptide research stemming from studies on the Growth Hormone molecule in the late 20th century. AOD-9604 is a shortened peptide sequence corresponding to the C-terminus of hGH (amino acids 177-191), designed specifically to isolate and enhance the metabolic functions of the hormone. Its name is an acronym for Anti-Obesity Drug, with the number indicating its specific iteration in the development pipeline.

What is the Mechanism of AOD-9604 Lipolysis?

The primary mechanism of action involves AOD-9604 selectively binding to beta-3 adrenergic receptors on adipocytes, or fat cells, initiating the breakdown of stored triglycerides into free fatty acids and glycerol. It functions by stimulating the activity of Hormone-Sensitive Lipase (HSL) and downregulating the expression of lipogenic enzymes, such as Acetyl-CoA Carboxylase, which are responsible for fat synthesis. This targeted activation promotes the mobilization and subsequent oxidation of fat without significantly affecting circulating Insulin-like Growth Factor-1 (IGF-1) levels.

AOD-9604 Lipolysis ∞ Area

AOD-9604 Lipolysis

Meaning

AOD-9604 Lipolysis refers to the specific biochemical process of fat breakdown induced by the synthetic peptide AOD-9604, a modified fragment of the human Growth Hormone (hGH) molecule. This peptide is structurally engineered to retain the lipolytic, or fat-releasing, effects of hGH while minimizing its impact on insulin resistance and overall growth promotion. Clinically, it is studied for its potential application in weight management and the reduction of adipose tissue mass.

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HRTioSeptember 30, 2025

AOD-9604 Lipolysis

Meaning

Origin

Mechanism

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