The strategic clinical use of non-pharmaceutical compounds, typically vitamins, minerals, herbal extracts, or amino acids, to mitigate symptoms of anxiety and promote a state of physiological calm. This intervention aims to support the body’s intrinsic stress response pathways and enhance emotional regulation without the side effects often associated with prescription anxiolytics. The goal is to restore neurochemical balance and reduce the overactivity of the sympathetic nervous system.
Origin
‘Anxiolytic’ derives from the Greek anxia (anxiety) and lytikos (able to loosen or dissolve), signifying its anxiety-reducing property. The practice of using ‘supplementation’ for this purpose originates from traditional and complementary medicine, which is now increasingly integrated into modern wellness protocols based on biochemical and neurobiological research. This approach recognizes the role of nutritional cofactors and adaptogens in mental health.
Mechanism
These supplements often function by modulating key inhibitory and excitatory neurotransmitter systems, primarily by enhancing the activity of the GABAergic pathway, which is the brain’s primary calming system. Certain compounds may also influence the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol output and dampening the chronic stress response. By supporting neurogenesis and reducing neuroinflammation, anxiolytic supplementation facilitates a more resilient and balanced central nervous system state.
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