The physiological and psychological capacity to regulate the intensity and duration of the body’s reaction to perceived stressors. This critical homeostatic process involves the endocrine and nervous systems working in concert to prevent a disproportionate or prolonged stress state. Effective control maintains emotional equilibrium and protects against the downstream negative effects of chronic cortisol and catecholamine elevation.
Origin
The concept stems from the integration of psychological stress models with the biological understanding of the Hypothalamic-Pituitary-Adrenal (HPA) axis and the autonomic nervous system. Clinical endocrinology and psychoneuroimmunology fields have been instrumental in defining this regulatory function. Understanding this control mechanism is foundational for treating anxiety-related endocrine dysregulation.
Mechanism
This control is primarily mediated by the negative feedback loop of the HPA axis, where cortisol inhibits the release of CRH and ACTH. Additionally, parasympathetic nervous system activation, often via the vagus nerve, counterbalances the sympathetic ‘fight or flight’ response. Modulating neuroendocrine pathways and enhancing inhibitory neurotransmitter function are key clinical strategies for improving anxiety response control.
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