Antioxidant defense represents the body’s intrinsic and acquired capacity to neutralize or mitigate the damaging effects of reactive oxygen species, often termed free radicals. These defenses are crucial for protecting cellular components, like DNA and lipids, from oxidative stress, which is a key driver of aging and hormonal dysfunction. Maintaining a robust antioxidant status is foundational for cellular health and the integrity of endocrine signaling pathways.
Origin
The concept combines “anti,” meaning against, and “oxidant,” referring to oxidizing agents, highlighting the counteraction of cellular oxidation. Defense is rooted in the body’s evolutionary necessity to survive an oxygen-rich environment where metabolic processes naturally generate unstable molecules. In endocrinology, this defense system is integral to protecting hormone-producing glands and hormone receptors from damage.
Mechanism
The mechanism involves enzymatic systems, such as superoxide dismutase, catalase, and glutathione peroxidase, alongside non-enzymatic molecules like vitamins C and E. These agents work synergistically to scavenge free radicals, converting them into less harmful compounds. Hormones, including sex steroids, also possess intrinsic antioxidant properties, further illustrating the interconnectedness of endocrine and redox systems in maintaining physiological balance.
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