What is the Origin of Anti-Senescence Therapy?

The concept originates from the molecular biology of aging, specifically the discovery and characterization of cellular senescence as a fundamental hallmark of the aging process. The term 'anti-senescence' combines the Greek/Latin root senex (old) with the therapeutic intent to reverse or halt this cellular aging. Its clinical application has grown significantly with advancements in senolytic and senomorphic drug development.

What is the Mechanism of Anti-Senescence Therapy?

Anti-senescence therapies primarily operate through two pathways: senolytics, which selectively induce apoptosis (programmed cell death) in senescent cells, and senomorphics, which alter the Senescence-Associated Secretory Phenotype (SASP) to reduce inflammation and tissue damage. By clearing or neutralizing these dysfunctional cells, the therapy aims to restore tissue microenvironments, improve organ function, and delay the onset of age-related endocrine dysregulation.

Anti-Senescence Therapy ∞ Area

Anti-Senescence Therapy

Meaning

A specialized therapeutic approach focused on targeting and eliminating senescent cells or mitigating their detrimental effects on tissue function and systemic health. Senescent cells, which have ceased dividing but remain metabolically active and secrete pro-inflammatory factors, are major contributors to age-related decline and chronic disease. This therapy is a core strategy in the pursuit of enhanced healthspan and biological longevity.