These are clinical or investigational interventions designed to counteract the fundamental biological processes leading to cellular aging, or senescence. The goal is to mitigate age-related physiological decline by targeting the hallmarks of aging at a molecular level. Such therapies aim to preserve tissue function and extend healthspan, which is distinct from chronological lifespan extension.
Origin
The term derives from the Greek “senex” meaning old, combined with “anti” and the biological study of senescence, the irreversible arrest of cell division. This concept has gained traction within regenerative medicine and gerontology research streams. It reflects a scientific push to manage biological age rather than simply treating the resulting diseases.
Mechanism
Mechanisms often involve senolytic clearance of senescent cells, modulation of sirtuin activity, or optimization of telomere maintenance pathways. Furthermore, these therapies might seek to restore epigenetic fidelity or improve mitochondrial function within compromised tissues. The objective is to reduce the inflammatory burden associated with accumulated senescent cells, thereby supporting overall tissue homeostasis.
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