What is the Origin of Anti-Senescence Molecules?

The term combines the prefix 'anti-' meaning against, with 'senescence,' derived from the Latin senescere, meaning 'to grow old.' The concept originated from gerontology and cell biology, evolving into a translational term within the longevity medicine space. The focus is on reversing or delaying the accumulation of dysfunctional, aged cells within tissues.

What is the Mechanism of Anti-Senescence Molecules?

Senolytics operate by inducing apoptosis specifically in senescent cells, thereby reducing the systemic burden of the Senescence-Associated Secretory Phenotype (SASP). The SASP involves the release of pro-inflammatory cytokines, chemokines, and proteases that damage surrounding healthy tissue and drive chronic inflammation. Senomorphics, conversely, work to suppress the harmful SASP components without necessarily killing the senescent cell.

Anti-Senescence Molecules ∞ Area

Anti-Senescence Molecules

Meaning

A class of pharmacological or naturally occurring compounds designed to target and mitigate the process of cellular senescence, which is the irreversible arrest of cell proliferation associated with aging. These molecules aim to either selectively eliminate senescent cells (senolytics) or modify their detrimental secretory phenotype (senomorphics). They represent a key focus in longevity and anti-aging research to improve healthspan.