What is the Origin of Anti-Senescence Agents?

This terminology originates directly from gerontology and molecular biology research, specifically the study of cellular senescence as a fundamental hallmark of aging. The development of agents to counteract this process represents a frontier in longevity science. The concept shifts the therapeutic focus from simply treating age-related diseases to addressing the root cellular causes of aging itself.

What is the Mechanism of Anti-Senescence Agents?

Senolytic agents function by inducing programmed cell death, or apoptosis, selectively in senescent cells by disrupting their pro-survival pathways. Senomorphic agents, conversely, modify the Senescence-Associated Secretory Phenotype (SASP), reducing the release of pro-inflammatory cytokines and proteases by these lingering cells. This dual approach aims to mitigate the systemic inflammation and tissue damage caused by senescent cell accumulation, promoting tissue regeneration and functional integrity.

Anti-Senescence Agents

Meaning

Anti-Senescence Agents, often referred to as senolytics or senomorphics, are a class of compounds designed to specifically target and eliminate senescent cells or modify their harmful secretory phenotype. Senescent cells are damaged cells that cease dividing but remain metabolically active, accumulating in tissues over time and contributing to chronic inflammation and tissue dysfunction. The clinical goal of these agents is to reduce the body’s senescent cell burden, thereby improving tissue function and extending healthspan.