Anti-Senescence refers to therapeutic or lifestyle strategies aimed at preventing, delaying, or reversing cellular senescence, a state where cells permanently cease dividing but remain metabolically active and secrete pro-inflammatory factors. This biological goal is critical for extending healthspan by reducing the burden of dysfunctional, aging cells within tissues. Senescent cells, often called “zombie cells,” contribute significantly to age-related decline and chronic disease development. Successfully implementing anti-senescence strategies can improve tissue function and vitality.
Origin
This term is rooted in the field of gerontology and molecular biology, specifically addressing one of the primary hallmarks of aging identified in extensive research. The prefix “anti” (against) and the root “senescence” (the process of deterioration with age) clearly define its counter-aging objective. Clinical application focuses on intervening in the fundamental processes of biological aging. It represents a paradigm shift in preventative medicine.
Mechanism
The mechanism involves selective clearance of senescent cells, often through senolytic agents, or suppressing their detrimental secretome, known as the Senescence-Associated Secretory Phenotype (SASP). Key pathways targeted include those regulating telomere length, DNA damage response, and the p53/p21 and p16/Rb tumor suppressor pathways. Modulating cellular energy metabolism and nutrient sensing pathways, such as mTOR and AMPK, also contributes to preventing the onset of senescence. These interventions aim to restore a state of cellular youth.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.