A sustained physiological condition characterized by a significant and clinically measurable reduction in the circulating levels of pro-inflammatory cytokines, chemokines, and acute-phase reactants, such as C-reactive protein (CRP) and Interleukin-6 (IL-6). Achieving this state is a core objective in preventative medicine, as chronic, low-grade systemic inflammation, often termed “inflammaging,” is a primary driver of age-related disease and hormonal dysregulation. The maintenance of an anti-inflammatory state supports robust cellular health and metabolic function.
Origin
This clinical concept evolved from the growing understanding of the critical role of chronic inflammation in the pathogenesis of non-communicable diseases, including cardiovascular disease, type 2 diabetes, and neurodegeneration. The focus shifted from merely treating acute inflammation to actively cultivating a state of resolution and systemic tranquility, emphasizing the body’s endogenous mechanisms for inflammation resolution. The term is central to modern functional and restorative medicine paradigms.
Mechanism
The induction of anti-inflammatory states is mediated through multiple systemic pathways, including the activation of the parasympathetic nervous system via the vagus nerve, which inhibits pro-inflammatory cytokine release. Hormonally, optimal levels of glucocorticoids, adiponectin, and sex steroids exert powerful immunosuppressive and anti-inflammatory effects. Furthermore, specialized pro-resolving mediators, derived from omega-3 fatty acids, actively terminate the inflammatory response and promote tissue repair, ensuring that the resolution phase is complete and chronic smoldering inflammation is avoided.
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