This describes the specific molecular activities exerted by small protein chains, or peptides, that serve to resolve or suppress aberrant inflammatory responses within tissues and systemic circulation. These actions are vital for preventing chronic, low-grade inflammation which drives many age-related pathologies. We are looking at targeted dampening of pro-inflammatory cascades.
Origin
The terminology merges ‘peptide,’ referring to short chains of amino acids, with ‘anti-inflammatory,’ a functional description of its role in modulating immune signaling. This field gained prominence as research illuminated the regulatory roles of endogenous signaling peptides in immune homeostasis. It represents a refined area within immunomodulation science.
Mechanism
These peptides often bind to specific cell surface receptors on immune cells, leading to the downregulation of NF-κB signaling or the inhibition of pro-inflammatory cytokine release, such as IL-6 or TNF-alpha. Some may directly interfere with leukocyte migration into inflamed sites. The result is a restoration of cellular quiescence and tissue health, moving away from chronic inflammatory states.
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