The clinical and physiological strategies intentionally utilized to mitigate chronic neuroinflammation to preserve optimal neural circuit function and maintain delicate endocrine balance. This crucial support is vital for protecting the central nervous system from the detrimental impact of inflammatory cytokines on essential neurotransmitter synthesis and hormone signaling pathways. It is a targeted approach to enhance the brain’s resilience against inflammatory stress.
Origin
This concept represents a clinical integration of systemic inflammation research, rooted in cellular pathology, with the neuroscientific understanding of neural tissue integrity and repair. It stems from a growing body of research that acknowledges the profound, bidirectional communication and feedback loops existing between the peripheral immune system and the central nervous system.
Mechanism
Support mechanisms typically involve the use of specific nutritional cofactors or pharmacological agents that modulate the activity of glial cells, such as microglia, which are the primary drivers of neuroinflammation. By dampening the excessive release of pro-inflammatory mediators, the integrity of the critical blood-brain barrier is maintained. This process fosters a healthier microenvironment essential for neuronal health and robust hormonal communication, particularly within the hypothalamic-pituitary-adrenal axis.
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