What is the Origin of Anti-Inflammatory Mechanisms?

The term reflects the counter-regulatory processes inherent in the immune system, designed to balance pro-inflammatory signals with resolution-promoting pathways. Clinical understanding evolved from simply treating inflammation with exogenous agents to recognizing the body's innate capacity for inflammatory resolution. This concept is central to immunophysiology and is increasingly studied in the context of age-related inflammatory states, or inflammaging.

What is the Mechanism of Anti-Inflammatory Mechanisms?

These processes involve the production of specialized pro-resolving mediators (SPMs), such as resolvins and protectins, derived from omega-3 fatty acids, which actively switch off neutrophil infiltration and promote efferocytosis. Endogenous hormones like cortisol and certain sex steroids can exert potent effects by inhibiting the transcription factors, such as NF-κB, that drive the expression of pro-inflammatory cytokines. This coordinated effort leads to the cessation of inflammatory signaling and the repair of damaged tissue microenvironments.

Anti-Inflammatory Mechanisms

Meaning

The physiological and molecular processes employed by the body to actively resolve or suppress chronic or acute inflammatory responses, thereby restoring tissue function and preventing collateral damage. These mechanisms are essential for regulating the immune system and maintaining a state of health, as unchecked inflammation contributes to numerous chronic diseases, including cardiovascular and neurodegenerative conditions. Hormonal balance often plays a regulatory role in these complex systemic responses.

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