A structured nutritional plan designed to systematically reduce chronic, low-grade systemic inflammation throughout the body. This protocol emphasizes the consumption of nutrient-dense foods rich in omega-3 fatty acids, antioxidants, and phytochemicals to modulate the inflammatory cascade. Clinically, its objective is to alleviate inflammatory stress, which can disrupt delicate hormonal signaling and metabolic homeostasis within the endocrine system. Adherence to the protocol is often monitored through patient-reported symptoms and specific laboratory biomarkers like C-reactive protein.
Origin
The concept stems from decades of epidemiological and clinical research linking specific dietary patterns to the incidence of chronic disease and persistent inflammatory processes. It represents a synthesis of principles derived from established dietary models, formalized into a clinical protocol for targeted intervention. The term gained prominence in the wellness and functional medicine spaces as a precise strategy against “inflammaging,” a key driver of age-related decline. Its application in hormonal health is rooted in the understanding that inflammation is a primary factor in endocrine dysfunctions, including insulin resistance and thyroid axis disruption.
Mechanism
The protocol operates by shifting the body’s eicosanoid balance away from pro-inflammatory mediators toward beneficial anti-inflammatory derivatives, primarily through the intake of specific fats. It strategically restricts common inflammatory triggers such as refined carbohydrates, trans fats, and known food sensitivities that perpetuate immune activation. High consumption of fiber and polyphenols supports gut microbiota diversity, which in turn reduces intestinal permeability and subsequent endotoxemia, a significant contributor to systemic inflammation and HPA axis dysregulation. This systemic reduction in inflammatory load directly improves cellular sensitivity to key metabolic and reproductive hormones.
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