What is the Origin of Anti-Inflammatory Biochemistry?

The concept stems from the integration of immunology, endocrinology, and metabolic science, where chronic inflammation is recognized as a central driver of many modern health issues. Etymologically, 'anti' means against, 'inflammatory' relates to fire or swelling, and 'biochemistry' is the chemistry of life. This framework acknowledges that simply suppressing inflammation is insufficient; active resolution is required for true wellness.

What is the Mechanism of Anti-Inflammatory Biochemistry?

This process involves the switch in eicosanoid production from pro-inflammatory prostaglandins and leukotrienes to anti-inflammatory lipoxins, resolvins, and protectins. Hormones, including cortisol and certain sex steroids, modulate the expression of key inflammatory genes like NF-κB, influencing the overall inflammatory cascade. Proper mitochondrial function and adequate nutrient cofactors are essential to power these resolution pathways, ensuring cellular tranquility and systemic resilience.

Anti-Inflammatory Biochemistry ∞ Area

Anti-Inflammatory Biochemistry

Meaning

The cellular and molecular processes that actively work to resolve chronic, low-grade systemic inflammation. This biochemical state is characterized by the regulated production of pro-resolving mediators, such as specialized pro-resolving mediators (SPMs), which facilitate tissue repair. Maintaining this balance is crucial for hormonal homeostasis and mitigating age-related physiological decline. It represents the body’s intrinsic capacity to shift from an inflammatory response to a healing phase.