Anti-inflammaging strategies encompass targeted clinical and lifestyle interventions designed to mitigate “inflammaging,” which is the chronic, low-grade, sterile systemic inflammation characteristic of aging. This persistent inflammatory state is a significant driver of age-related decline and chronic disease pathology. Effective strategies focus on reducing the production of pro-inflammatory cytokines and shifting the physiological balance toward an anti-inflammatory state. These interventions are integral to longevity protocols, recognizing that hormonal decline and inflammation are often mutually reinforcing.
Origin
The term “inflammaging” was coined by scientists in the early 2000s, synthesizing the observations that aging is universally accompanied by elevated markers of inflammation, even in the absence of acute infection. This concept moved the focus of aging research from passive decline to active, measurable pathological processes. Anti-inflammaging strategies arose clinically as a response to this scientific understanding, providing a framework for managing the systemic inflammatory burden that accelerates biological aging.
Mechanism
These strategies operate by modulating key inflammatory pathways, such as the NF-κB signaling cascade, which controls the expression of numerous inflammatory genes. Nutritional interventions, like omega-3 fatty acids, can shift eicosanoid balance towards less inflammatory mediators. Furthermore, optimizing hormonal status, particularly maintaining adequate levels of sex steroids and cortisol rhythm, helps regulate immune cell function and dampens the chronic inflammatory response. The overall mechanism aims to suppress the senescent-associated secretory phenotype (SASP) and restore immune-endocrine equilibrium.
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