Clinically defined strategies and interventions designed to mitigate the chronic, low-grade, sterile inflammation known as “inflammaging,” a key driver of age-related physiological decline and chronic disease pathogenesis. These protocols aim to restore immune homeostasis and reduce the systemic burden of pro-inflammatory cytokines. This proactive approach supports healthy longevity by preserving tissue function and delaying the onset of age-associated dysfunction.
Origin
The term is a compound derived from “anti,” meaning against, and “inflammaging,” a portmanteau coined by scientists to describe the persistent, age-related inflammatory status. It belongs firmly to the domain of geroscience and preventative medicine, emphasizing inflammation’s central role in the aging phenotype.
Mechanism
Protocols function by modulating critical inflammatory pathways, such as the NF-κB signaling cascade, which governs the expression of numerous pro-inflammatory genes. Nutritional adjustments, targeted supplementation with anti-inflammatory molecules, and lifestyle modifications, like regular exercise, serve to suppress the inflammasome activation and enhance the resolution phase of inflammation. The goal is to lower circulating inflammatory markers, thereby reducing cellular stress and supporting systemic resilience.
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