What is the Origin of Anti-Inflammaging?

The term itself is a portmanteau, combining "anti-inflammatory" and "aging," coined by scientists to describe the direct link between chronic inflammation and the aging phenotype. This concept shifted the focus of longevity research from merely observing damage to actively intervening in the underlying inflammatory cascade. It recognizes that persistent immune system activation, rather than acute infection, contributes significantly to age-related morbidity.

What is the Mechanism of Anti-Inflammaging?

The core mechanism involves modulating pro-inflammatory cytokines, such as IL-6 and TNF-alpha, while promoting the activity of anti-inflammatory mediators. Interventions often target the nuclear factor kappa B (NF-κB) pathway, a master regulator of inflammation, and seek to improve gut barrier function to reduce the translocation of microbial products into the systemic circulation. By calming this persistent molecular fire, anti-inflammaging efforts protect tissues and organs from chronic, cumulative inflammatory damage.

Anti-Inflammaging

Meaning

Anti-Inflammaging is a specialized clinical strategy focused on mitigating “inflammaging,” the chronic, low-grade, sterile inflammation that characterizes biological aging. This persistent systemic inflammation is a key driver of age-related diseases and functional decline. The strategy involves targeted nutritional, lifestyle, and therapeutic interventions to dampen the inflammatory response and restore immune balance. Successful anti-inflammaging protocols aim to extend healthspan by reducing the underlying molecular stress that accelerates senescence.