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Anti-Fragile Physiology

Meaning

Anti-Fragile Physiology describes the adaptive capacity of human systems, particularly the endocrine and metabolic axes, to benefit and strengthen when exposed to hormetic stressors. This state moves beyond simple resilience, indicating a system that improves its functional set-points following controlled challenge. In a clinical context, it refers to the body’s ability to enhance hormonal output or receptor sensitivity after appropriate, non-damaging physiological perturbation. Maintaining this dynamic adaptability is central to long-term healthspan.