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Anti-Fibrotic Tissue Remodeling

Meaning

The clinical process of actively inhibiting the pathological accumulation of excess extracellular matrix components, primarily collagen, and promoting the restoration of normal tissue architecture and function. Fibrosis represents a maladaptive wound healing response that impairs organ function, and this remodeling aims to mitigate that damage. This therapeutic strategy is critical in maintaining the functional capacity of vital organs like the heart, liver, and skin, which are often compromised by chronic inflammation or aging.