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Anti-Drug Antibody Surveillance

Meaning

Anti-Drug Antibody Surveillance is the clinical practice of systematically monitoring a patient’s immune response against an administered therapeutic compound, particularly biologics like peptide hormones or monoclonal antibodies. The goal is to detect the formation of antibodies that neutralize the drug or alter its pharmacokinetics, which can lead to diminished clinical efficacy or unexpected adverse reactions. This critical assessment ensures the sustained effectiveness and safety of hormonal treatments over time. A proactive approach to immunogenicity allows for timely adjustment of the treatment strategy.