Interventions specifically designed within the scope of longevity science to mitigate the physiological decline associated with chronological aging. These modalities target fundamental biological processes, such as telomere attrition or senescent cell accumulation, rather than merely treating symptomatic age-related conditions. Our focus here remains on preserving endocrine function and tissue integrity across the lifespan.
Origin
The term originates from gerontology, evolving to incorporate concepts from molecular biology and endocrinology as research illuminated the hormonal underpinnings of senescence. Early concepts focused on lifestyle, but modern modalities now include targeted pharmacological and biological agents. This evolution reflects a shift from managing decline to actively promoting resilience at the cellular level.
Mechanism
Modalities operate by influencing pathways such as mTOR signaling, sirtuin activation, or growth hormone/IGF-1 axis modulation to promote anabolism and reduce catabolism. Successful implementation aims to restore youthful gene expression patterns and improve mitochondrial efficiency within key tissues. These actions collectively seek to delay the onset of age-associated physiological dysfunction, supporting robust vitality.
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