This term describes targeted clinical strategies aimed at favorably altering the biological progression associated with senescence, often focusing on endocrine optimization and cellular resilience. It is not about stopping time but about preserving functional capacity over the lifespan. We seek to shift the trajectory away from decline toward sustained vitality through evidence-based interventions.
Origin
Derived from gerontology and longevity science, the concept integrates concepts of biological age versus chronological age. The trajectory component references the predictable decline curves observed in key biomarkers, such as telomere attrition or anabolic hormone levels. Modification implies proactive, measurable influence on these biological timelines.
Mechanism
Modification often involves optimizing anabolic signaling pathways, enhancing mitochondrial efficiency, and managing chronic low-grade inflammation, sometimes termed inflammaging. Interventions may include optimizing growth hormone axis function or ensuring robust sex steroid receptor expression. These actions aim to improve cellular repair mechanisms, thereby slowing detrimental physiological drift.
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