A combination of pharmacological agents, peptides, or nutraceuticals administered concurrently to target multiple, interconnected hallmarks of biological aging within the hormonal and metabolic systems. These stacks are constructed based on an understanding of synergistic effects aimed at enhancing cellular resilience and mitigating senescence. The approach is inherently multi-target, reflecting the complexity of the aging phenotype.
Origin
This terminology arises from the intersection of advanced longevity research and practical application, often involving the sequential or parallel deployment of compounds that influence telomere maintenance, NAD+ metabolism, or receptor downregulation. It signifies a proactive, combinatorial approach to healthspan extension.
Mechanism
The therapeutic stack functions by simultaneously addressing deficits in different physiological domains; for instance, combining a compound that enhances mitochondrial biogenesis with one that improves insulin sensitivity. This coordinated attack aims to restore cellular homeostasis more effectively than any single agent acting in isolation on a specific endocrine pathway.
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