Clinical interventions aimed at modulating physiological processes associated with senescence, often focusing on optimizing endocrine function for healthspan extension. These applications target cellular hallmarks of aging to promote resilience and functional capacity. We seek to restore youthful endocrine profiles rather than merely extending lifespan in a compromised state. Such applications require precise assessment of individual hormonal baselines.
Origin
Derived from the convergence of gerontology and clinical endocrinology, emphasizing proactive management of age-related decline in hormone levels and receptor sensitivity. The concept shifts focus from treating disease to optimizing intrinsic biological maintenance systems. This approach recognizes that many age-related pathologies share underlying hormonal dysregulation.
Mechanism
Often involves supporting endogenous hormone production, enhancing receptor affinity, or employing hormone replacement therapies at physiologic levels. Key pathways include modulating the somatopause, andropause, or menopause through targeted endocrine support. Effective application requires understanding feedback loops and minimizing allostatic load on the hypothalamic-pituitary-adrenal (HPA) axis.
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