This represents a highly integrated, data-driven approach to longevity and healthspan optimization, treating the human body as a complex biological system. It involves the clinical application of engineering principles—such as control theory and feedback loops—to the fundamental processes of biological aging. The focus is on identifying and modulating multiple interconnected aging pathways, including cellular senescence, mitochondrial dysfunction, and hormonal decline. This comprehensive strategy seeks to maintain optimal physiological function well into advanced age.
Origin
The term combines concepts from gerontology and biomedical engineering, particularly the emerging field of systems biology. Its origin lies in the clinical translation of advanced research into the Hallmarks of Aging, shifting the paradigm from reactive disease treatment to proactive, multi-factor biological maintenance. The “Engineering” aspect emphasizes precise, measurable, and repeatable interventions based on objective biological data.
Mechanism
The mechanism centers on utilizing advanced diagnostics to map an individual’s unique biological network and identify key regulatory nodes of the aging process. Interventions are then precisely calibrated to restore youthful function across multiple systems simultaneously. This involves modulating key longevity pathways like mTOR and AMPK, optimizing cellular energy production, and restoring endocrine signaling cascades to a younger, more robust profile.
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