Anti-Aging Supplements are nutraceutical agents or compounds ingested with the primary clinical goal of modulating physiological pathways associated with the aging process and age-related functional decline. The objective is to support cellular health, enhance metabolic function, and optimize hormonal balance, thereby extending healthspan, which is the period of life lived in good health. These agents are designed to complement a healthy lifestyle and may target mechanisms of senescence. Clinical efficacy requires rigorous evaluation against specific biomarkers of aging, such as telomere dynamics or inflammatory cytokine profiles.
Origin
The concept of using external substances to combat senescence has historical roots, but the modern category emerged with the rise of nutritional science and the increased molecular understanding of aging in the late 20th century. The term is broadly used in the wellness space to describe compounds like NAD+ precursors, senolytics, and specific hormone-supportive vitamins or minerals. Their clinical relevance is increasingly studied in the context of personalized longevity medicine protocols.
Mechanism
These supplements target fundamental mechanisms of aging, often focusing on enhancing mitochondrial biogenesis, reducing cellular senescence, and mitigating oxidative stress. Many aim to support the endogenous production or activity of key metabolic cofactors, such as boosting NAD+ levels to enhance sirtuin activity for DNA repair. Others may function as potent antioxidants or modulate inflammatory cytokines, indirectly influencing the endocrine system’s ability to maintain optimal homeostasis and regenerative capacity.
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