The clinical strategy focused on recalibrating aberrant cellular and systemic communication pathways that drive the aging phenotype. This approach seeks to restore youthful homeostatic signaling dynamics within the endocrine, metabolic, and neurological systems. It addresses the decline in hormonal responsiveness and receptor sensitivity that characterizes biological senescence. The ultimate goal is to optimize cellular function and physiological reserve, thereby mitigating age-related functional decay.
Origin
This term originates from the convergence of gerontology research, endocrinology, and precision medicine, emphasizing a shift from merely treating age-related diseases to actively managing the underlying signaling dysregulation of aging itself. It reflects a contemporary understanding that aging is fundamentally a loss of information fidelity and communication efficiency within the biological network. The concept is rooted in the study of conserved longevity pathways, such as those involving sirtuins and mTOR.
Mechanism
The correction mechanism involves targeted interventions that influence key molecular switches, often including pharmacological agents or lifestyle modifications that mimic pro-longevity states. These interventions aim to reset endocrine feedback loops, enhance cellular stress response pathways like autophagy, and improve mitochondrial biogenesis. By restoring appropriate signal transduction, the body’s intrinsic repair and maintenance systems are reactivated, promoting tissue resilience and functional integrity.
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