The systematic application of biomedical research to slow, halt, or reverse age-related physiological decline. This field focuses on understanding the fundamental molecular and cellular processes contributing to senescence and functional deterioration. It moves beyond simple cosmetic concerns to address systemic health maintenance across the lifespan. Clinical practice within this domain seeks to preserve tissue homeostasis and optimize organ function against time-dependent degradation.
Origin
Derived from the broader concept of longevity research, the term emphasizes an active, scientific approach rather than passive acceptance of aging as inevitable. In endocrinology, it connects strongly to understanding age-related changes in hormone production and signaling pathways. The lexicon reflects a shift toward proactive healthspan extension through targeted biological intervention.
Mechanism
Interventions often target hallmarks of aging such as genomic instability, telomere attrition, and epigenetic alterations. Modulating anabolic signaling pathways, like the somatotropic axis, is a common focus area. Furthermore, optimizing cellular energy metabolism and mitigating chronic low-grade inflammation, or “inflammaging,” are central mechanistic goals.
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