This refers to the clinical application and logistical method of introducing specific compounds, which are theorized to slow or reverse aspects of cellular aging, into the human body. The focus is on optimizing bioavailability and systemic distribution to reach target tissues effectively. Examples include the precise administration of sirtuin activators or NAD+ precursors to influence longevity pathways.
Origin
The concept stems from pharmacology and gerontology, where research identified molecules influencing fundamental aging hallmarks like cellular senescence and mitochondrial dysfunction. The ‘delivery’ aspect highlights the pharmaceutical engineering challenge of getting these often-unstable or poorly absorbed molecules to their site of action. This clinical necessity drives innovation in encapsulation and formulation science.
Mechanism
Effective delivery systems, such as specialized enteric coatings or liposomal encapsulation, are utilized to protect the molecule from premature degradation in the digestive tract or bloodstream. Once delivered, these compounds typically modulate key longevity pathways, including AMPK or sirtuins, to enhance DNA repair, improve metabolic efficiency, and promote overall cellular resilience against age-related stress.
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