These are structured, evidence-based regimens encompassing nutrition, physical activity, sleep optimization, and targeted supplementation designed to mitigate the biological processes of senescence and promote healthspan. The protocols aim to optimize endocrine function, enhance cellular repair mechanisms, and reduce chronic systemic inflammation, which are primary drivers of age-related decline. Implementing these comprehensive strategies supports the maintenance of physiological function at a more youthful level. This holistic approach focuses on modifying modifiable lifestyle factors to influence epigenetic expression and longevity pathways.
Origin
The term synthesizes concepts from gerontology, preventive medicine, and the burgeoning field of longevity science. Its foundation lies in observing the impact of environmental and behavioral factors on lifespan and healthspan, translating scientific findings into actionable daily habits. The development of formalized protocols stems from clinical attempts to systematically apply research on caloric restriction, intermittent fasting, and exercise endocrinology to a patient’s daily life. This is a practical application of the science of biogerontology.
Mechanism
These protocols function by influencing core cellular aging pathways, including mTOR, AMPK, and sirtuin signaling, which govern nutrient sensing and cellular stress response. Strategic exercise can enhance mitochondrial biogenesis and improve insulin sensitivity, crucial for metabolic health. Furthermore, optimized sleep and stress management directly regulate the production of anabolic hormones like growth hormone and testosterone while reducing catabolic cortisol exposure. The cumulative effect is a reduction in cellular damage, promotion of autophagy, and stabilization of telomere length, thus decelerating biological aging.
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