The highly individualized, data-driven methodology for selecting and administering therapies aimed at mitigating biological aging processes. This clinical approach relies on a comprehensive assessment of biomarkers, genetic predispositions, and lifestyle factors to tailor interventions for maximum efficacy and minimal adverse effects. Precision in this context moves beyond generalized protocols to target specific mechanisms of cellular senescence.
Origin
This concept evolved from the general field of gerontology and the subsequent rise of personalized medicine, emphasizing molecular and cellular heterogeneity among individuals. The addition of ‘Precision’ signifies the integration of advanced diagnostics, such as epigenetics and deep phenotyping, into the clinical application of longevity strategies.
Mechanism
Achieving precision involves identifying and targeting the individual’s dominant aging hallmarks, which may include mitochondrial dysfunction, telomere attrition, or chronic sterile inflammation. Interventions, which can range from pharmacological agents to lifestyle modifications, are selected based on their known effect on these specific cellular pathways. The goal is to optimize cellular function and hormonal signaling with an exact, evidence-based approach.
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