What is the Origin of Anti-Aging Geroscience?

The term is a modern compound, merging the concept of "anti-aging" with "geroscience," which is derived from the Greek geron meaning "old man" and scientia meaning "knowledge." This distinct field emerged from the convergence of molecular biology, genetics, and clinical medicine in the late 20th century. Its foundation lies in the recognition that diverse chronic diseases share common molecular and cellular pathways rooted in the biology of aging.

What is the Mechanism of Anti-Aging Geroscience?

Geroscience interventions focus on modulating the core hallmarks of aging, such as cellular senescence, mitochondrial dysfunction, altered nutrient sensing pathways, and chronic sterile inflammation. By targeting master regulatory pathways like mTOR, AMPK, or sirtuins, researchers aim to enhance cellular repair mechanisms and improve stress resistance. The mechanism is systemic, designed to slow the accumulation of cellular damage and restore homeostatic balance across multiple organ systems.

Anti-Aging Geroscience

Meaning

An advanced, interdisciplinary scientific field that targets the fundamental biological processes of aging with the goal of extending the healthy, functional lifespan, known as healthspan. This discipline views aging itself as the primary risk factor for chronic diseases, including cardiovascular, neurodegenerative, and metabolic disorders. Geroscience seeks to develop therapeutic interventions that modify the trajectory of senescence rather than merely treating individual age-related pathologies.