These are specific compounds or therapeutic agents designed to slow, halt, or partially reverse the underlying molecular and cellular damage associated with aging. Within the context of hormonal health, geroprotectors aim to preserve endocrine function and cellular vitality over time. We view these as interventions targeting the hallmarks of aging itself.
Origin
The term merges ‘anti-aging,’ reflecting the goal of extending healthspan, with ‘geroprotector,’ derived from Greek ‘geron’ (old man) and Latin ‘protegere’ (to guard). This nomenclature originates from the field of geroscience, which studies the fundamental biology of aging.
Mechanism
Geroprotectors often function by influencing conserved longevity pathways such as mTOR, AMPK, or sirtuins. They may also act to clear senescent cells, improve mitochondrial bioenergetics, or stabilize telomere length. In the endocrine domain, they support the integrity of hormone synthesis and receptor sensitivity against age-related decline.
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