The strategic implementation of diagnostic and therapeutic protocols designed to modulate the physiological processes associated with senescence, aiming to extend healthspan rather than merely chronological lifespan. This involves assessing biomarkers related to cellular vitality, telomere length, and epigenetic drift. Clinical application focuses on optimizing endocrine function to support tissue repair and maintenance.
Origin
This concept emerges from the intersection of gerontology and clinical endocrinology, focusing on proactive physiological intervention. The term signifies a shift from treating age-related pathology to preemptively managing the underlying biological drivers of decline. Its application is rooted in understanding how hormonal balance dictates cellular aging trajectories.
Mechanism
Key mechanisms involve optimizing growth hormone/IGF-1 axis signaling, supporting mitochondrial efficiency, and managing chronic low-grade inflammation, often termed “inflammaging.” Targeted hormone replacement or modulation may be utilized to restore youthful receptor expression patterns. Successful application relies on reducing oxidative stress burdens that accelerate macromolecular damage.
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