Anti-Aging Chemistry encompasses the study and application of exogenous or endogenous compounds designed to modulate the core biochemical pathways associated with biological senescence and functional decline. This field seeks to optimize cellular maintenance processes, including DNA repair, mitochondrial function, and the reduction of advanced glycation end-products (AGEs). Ultimately, it aims to extend the period of peak physiological function, often termed healthspan.
Origin
The concept draws its etymological roots from the ancient pursuit of longevity, modernized by breakthroughs in molecular biology and gerontology over the last century. Specifically, it integrates principles from pharmacology and endocrinology to address molecular damage accumulation. The chemistry component emphasizes the tangible molecular targets within metabolic and signaling cascades.
Mechanism
Interventions frequently target pathways such as sirtuin activation, NAD+ precursor supplementation, or the modulation of mTOR signaling to influence cellular resilience. These chemical adjustments seek to restore youthful cellular homeostasis, improving outcomes related to tissue regeneration and reducing oxidative stress burdens. Proper integration requires careful assessment of individual metabolic profiles to ensure efficacy and safety.
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