This refers to a multifaceted approach encompassing lifestyle, nutritional, and pharmacological interventions specifically designed to counteract age-related cognitive decline and maintain optimal cerebral function. These strategies focus on enhancing neuronal health, preserving synaptic integrity, and mitigating the impact of chronic systemic inflammation on the central nervous system. The goal is to sustain peak cognitive performance, including memory, processing speed, and executive function, well into later life.
Origin
The concept emerged from the intersection of gerontology, neuroscience, and longevity medicine, gaining prominence as life expectancy increased and the burden of neurodegenerative diseases became more apparent. The term reflects a shift from merely treating cognitive deficits to proactively implementing preventative measures rooted in understanding the molecular mechanisms of brain aging.
Mechanism
Strategies operate by modulating key physiological pathways implicated in brain aging, such as promoting neurogenesis, enhancing cerebral blood flow, and optimizing mitochondrial energy production within neurons. Hormonal balance, particularly the regulation of neurosteroids and thyroid hormones, plays a critical modulatory role in supporting synaptic plasticity and neuronal repair processes. Furthermore, these protocols often target the reduction of oxidative stress and the clearance of aggregated proteins, which are hallmarks of neurodegeneration.
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