This specialized field integrates endocrinology, neuroscience, and gerontology to understand and mitigate the physiological drivers of cognitive aging. It focuses on maintaining structural integrity and functional capacity of the central nervous system across the lifespan. Clinical interventions in this domain target systemic factors like hormonal balance, inflammation, and metabolic health to preserve brain vitality.
Origin
Its foundation stems from the convergence of longevity research and the clinical observation that cognitive decline is not an inevitable, uniform process but is significantly influenced by modifiable biological factors. The term crystallizes the shift from treating established neurological disease to proactive, preventative optimization of the neuroendocrine environment. This scientific discipline acknowledges the brain as an endocrine target organ highly sensitive to systemic hormonal fluctuations.
Mechanism
The core mechanism involves the preservation of neuroplasticity and the reduction of cellular senescence in brain tissue. Strategies often include optimizing the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes to maintain neurohormone levels critical for synaptic health. Furthermore, reducing chronic, low-grade systemic inflammation, which is a major driver of neurodegeneration, is a central tenet of this science.
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