This term denotes the clinical application of interventions aimed at regulating and optimizing fundamental biological processes that drive senescence. It represents a proactive strategy to mitigate the functional decline associated with chronological aging at the cellular and systemic levels. The goal is to sustain youthful physiological function and enhance resilience against age-related pathology.
Origin
The concept is rooted in gerontology and endocrinology, merging the scientific study of aging (“anti-aging”) with the clinical focus on modulating internal physiological systems (“biological control”). This phrase emerged from the paradigm shift towards preventative and regenerative medicine, emphasizing control over biological determinants of longevity.
Mechanism
Control is exerted through the targeted modulation of key endocrine pathways, cellular energy production via mitochondria, and genomic stability. This involves balancing hormonal axes like the HPA and HPG, optimizing nutrient sensing pathways such as mTOR and sirtuins, and maintaining telomere length and epigenetic integrity. Successful biological control slows the accumulation of molecular damage, thereby extending the period of high-quality function.
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